List of Famous people born in Río Negro Department, Uruguay

Giorgian Daniel de Arrascaeta Benedetti is a Uruguayan professional footballer who plays as an attacking midfielder for Campeonato Brasileiro Série A club Flamengo and the Uruguay national team.

Lucas Sebastián Torreira Di Pascua is a Uruguayan professional footballer who plays as a midfielder for La Liga club Atlético Madrid, on loan from Arsenal, and the Uruguay national team.

Gastón Exequiel Ramírez Pereyra is a Uruguayan footballer who plays as an attacking midfielder for Italian club U.C. Sampdoria.

Esteban Néstor Conde Quintana is a Uruguayan footballer who plays as a goalkeeper for Atenas.

Nicolás Milesi Van Lommel is a Uruguayan professional footballer who plays for Libertad as a midfielder.

Heriberto Andrés Bodeant Fernández is a Uruguayan Roman Catholic cleric.